Discover the Best Multi-Country Itineraries in Central America – Starting from Panama

If you’ve been dreaming of exploring Central America, few places offer the diversity, accessibility, and beauty that Panama does. Thanks to its strategic location and world-class connectivity, Panama makes the perfect starting point for an unforgettable multi-country vacation through Costa Rica, Nicaragua, Belize, and Guatemala.

A recent feature in Travel + Leisure highlights how travelers can craft seamless itineraries across the region—many of which begin right here in Panama.

Why Start in Panama?

Panama is more than just the Panama Canal and the modern skyline of Panama City. The country offers an incredible mix of history, culture, and natural wonders:

• Casco Antiguo – a UNESCO World Heritage site with colonial architecture, vibrant restaurants, and nightlife.

• El Valle de Antón – a picturesque town set in a volcanic crater, perfect for eco-tourism and relaxation.

• Boquete in Chiriquí – known for its cloud forests, coffee farms, and access to Volcán Barú.

• Pacific Coast Beaches – Panama’s Pacific side is famous for its beach communities:

  • Coronado – one of the most developed beach towns, popular with expats and retirees, with restaurants, shopping, and golf.

  • San Carlos – a quieter coastal town known for surfing, fishing, and beachfront living.

  • Vistamar – a luxury gated community offering golf, marina access, and upscale real estate opportunities.

• Pristine Islands – from the Caribbean’s San Blas Islands to the Pacific’s Coiba Island, Panama is a paradise for ocean lovers.

With this mix of city life, mountain retreats, and beach escapes, Panama is the ideal gateway to explore its neighbors.

The Panama–Costa Rica–Nicaragua Route

According to the Travel + Leisure itinerary, one of the most popular routes begins in Panama before heading north:

• Costa Rica – cross into the Osa Peninsula for jungle adventures, wildlife encounters, and eco-lodges. Continue to Monteverde for cloud forests and the Nicoya Peninsula, one of the world’s famous “Blue Zones.”

• Nicaragua – experience the charm of Granada’s colonial architecture, explore Lake Nicaragua, and hike Mombacho Volcano for breathtaking views.

The Belize–Guatemala Experience

For those who prefer a different route, starting in Panama also makes it easy to connect via short flights to Belize and Guatemala:

• Belize – discover ancient Mayan ruins such as Caracol, enjoy underwater cave adventures, and relax in luxury resorts on the Caribbean.

• Guatemala – visit the UNESCO-listed Tikal National Park, the stunning Lake Atitlán, and the colorful cobblestone streets of Antigua Guatemala.

Living in Panama: Your Base for Exploration

One of the best parts about living in Panama is that you’re at the heart of Central America. Whether you’re relocating, investing in real estate, or looking for a vacation home, Panama offers not only a high quality of life but also direct access to the wonders of the entire region.

Imagine owning property in Panama City, Boquete, or along the Pacific beaches of Coronado, San Carlos, or Vistamar, and being just a short flight or scenic drive away from some of the most exciting destinations in Central America.

Final Thoughts

Central America is rich in culture, adventure, and natural beauty. With Panama as your home base, you can easily explore Costa Rica, Nicaragua, Belize, and Guatemala—all while enjoying the comfort and convenience of living in one of the region’s most dynamic countries.

For more inspiration on multi-country itineraries, check out the full article from Travel + Leisure here.